We thank the discussants for their kind comments and their insightful analysis and discussion that has substantially added to the contribution of this issue. Overall, it seems the discussants have affirmed many of our primary points, and have also raised a number of other relevant and important issues that we did not emphasize in the paper. Several common threads emerged from these discussions, including the importance of software development, appropriate dissemination, and close collaboration with biomedical scientists and technology experts in order to ensure our work is relevant and impactful. Each discussant also mentioned other areas of bioinformatics that have been impacted by statistical researchers that we did not highlight in the original paper. In response, we will first summarize discuss these general themes, and then respond to specific comments of each discussant, and finally talk about the additional areas of bioinformatics impacted by statisticians that were mentioned by the reviewers.

中文翻译：

---

反驳生物信息学的统计贡献：设计、建模、结构学习和集成

我们感谢讨论者的友好评论以及他们富有洞察力的分析和讨论，这些都大大增加了本期的贡献。总的来说，讨论者似乎肯定了我们的许多主要观点，并且还提出了一些我们在论文中没有强调的其他相关且重要的问题。这些讨论中出现了几个共同点，包括软件开发、适当传播以及与生物医学科学家和技术专家密切合作的重要性，以确保我们的工作具有相关性和影响力。每位讨论者还提到了受统计研究人员影响的其他生物信息学领域，我们在原始论文中没有强调这些领域。作为回应，我们将首先总结讨论这些一般主题，