BACKGROUND Selenium is an essential trace element and is suggested to play a role in the etiology of a number of chronic diseases. Genetic variation in genes encoding selenoproteins, such as selenoprotein P and the glutathione peroxidases, may affect selenium status and, thus, individual susceptibility to some chronic diseases. In the present study, we aimed to (1) investigate the effect of mussel and fish intake on glutathione peroxidase enzyme activity and (2) examine whether single nucleotide polymorphisms in the GPX1, GPX4, and SELENOP genes modify the effect of mussel and fish intake for 26 weeks on whole blood selenium, plasma selenoprotein P concentrations, and erythrocyte GPX enzyme activity in a randomized intervention trial in Denmark. RESULTS CC homozygotes of the SELENOP/rs3877899 polymorphism who consumed 1000 g fish and mussels per week for 26 consecutive weeks had higher levels of both selenoprotein P (difference between means - 4.68 ng/mL (95% CI - 8.49, - 0.871)) and whole blood selenium (difference between means - 5.76 (95% CI - 12.5, 1.01)) compared to fish and mussel consuming T-allele carriers although the effect in whole blood selenium concentration was not statistically significant. CONCLUSIONS Our study indicates that genetically determined variation in SELENOP leads to different responses in expression of selenoproteins following consumption of selenium-rich foods. This study also emphasizes the importance of taking individual aspects such as genotypes into consideration when assessing risk in public health recommendations.

中文翻译：

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在丹麦的一项随机饮食干预研究中，硒蛋白 P 的遗传多态性改变了对富含硒的食物对血液中硒和硒蛋白 P 水平的反应。

背景技术硒是一种必需的微量元素，被认为在许多慢性疾病的病因学中发挥作用。编码硒蛋白的基因（如硒蛋白 P 和谷胱甘肽过氧化物酶）的遗传变异可能会影响硒的状态，从而影响个体对某些慢性疾病的易感性。在本研究中，我们旨在 (1) 研究贻贝和鱼类摄入对谷胱甘肽过氧化物酶活性的影响，以及 (2) 检查 GPX1、GPX4 和 SELENOP 基因中的单核苷酸多态性是否会改变贻贝和鱼类摄入的影响在丹麦的一项随机干预试验中，对全血硒、血浆硒蛋白 P 浓度和红细胞 GPX 酶活性进行了为期 26 周的研究。结果 连续 26 周每周食用 1000 g 鱼和贻贝的 SELENOP/rs3877899 多态性 CC 纯合子的硒蛋白 P 水平较高（平均值差异 - 4.68 ng/mL (95% CI - 8.49, - 0.871)）和全血硒（平均值之间的差异 - 5.76 (95% CI - 12.5, 1.01)）与食用 T 等位基因携带者的鱼和贻贝相比，尽管全血硒浓度的影响没有统计学意义。结论 我们的研究表明，遗传决定的 SELENOP 变异导致食用富含硒的食物后硒蛋白表达的不同反应。本研究还强调了在评估公共卫生建议中的风险时考虑基因型等个体方面的重要性。