Glioblastoma multiforme (GBM) is the most common primary tumor of the central nervous system. The serum and glucocorticoid-regulated kinase SGK1 gene is required for the growth and survival of GBM stem-like cells under both normoxic and hypoxic conditions. It has been reported that oxygenation significantly affects cellular genetic expression; 30% of the genes required in hypoxia were not required under normoxic conditions. Therefore, we examined SGK1 expression to determine if it may be a novel potential drug target for GBM.

中文翻译：

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多形性胶质母细胞瘤：SGK1基因较少的肿瘤拷贝数节段与较差的存活率相关。

多形胶质母细胞瘤（GBM）是中枢神经系统最常见的原发肿瘤。在常氧和低氧条件下，GBM干样细胞的生长和存活都需要血清和糖皮质激素调节的激酶SGK1基因。据报道，氧合作用显着影响细胞的遗传表达。低氧条件下不需要缺氧所需基因的30％。因此，我们检查了SGK1表达，以确定它是否可能是GBM的新型潜在药物靶标。