Long non-coding RNAs (lncRNAs) have been revealed to play essential roles in the human cardiovascular system. However, information about their mechanisms is limited, and a comprehensive view of cardiac lncRNAs is lacking from a multiple tissues perspective to date. Here, the landscape of the lncRNA transcriptome in human heart was summarized. We summarized all lncRNA transcripts from publicly available human transcriptome resources (156 heart samples and 210 samples from 29 other tissues) and systematically analysed all annotated and novel lncRNAs expressed in heart. A total of 7485 lncRNAs whose expression was elevated in heart (HE lncRNAs) and 453 lncRNAs expressed in all 30 analysed tissues (EIA lncRNAs) were extracted. Using various bioinformatics resources, methods and tools, the features of these lncRNAs were discussed from various perspectives, including genomic structure, conservation, dynamic variation during heart development, cis-regulation, differential expression in cardiovascular diseases and cancers as well as regulation at transcriptional and post-transcriptional levels. Afterwards, all the features discussed above were integrated into a user-friendly resource named CARDIO-LNCRNAS (http://bio-bigdata.hrbmu.edu.cn/CARDIO-LNCRNAS/ or http://www.bio-bigdata.net/CARDIO-LNCRNAS/). This study represents the first global view of lncRNAs in the human cardiovascular system based on multiple tissues and sheds light on the role of lncRNAs in developments and heart disorders.

中文翻译：

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人类心脏中长的非编码RNA转录组的景观。

长期的非编码RNA（lncRNA）已被揭示在人类心血管系统中起重要作用。然而，关于它们的机制的信息是有限的，并且从多个组织的角度看，迄今为止尚缺乏对心脏lncRNAs的全面了解。在这里，总结了人心脏中lncRNA转录组的情况。我们总结了来自可公开获得的人类转录组资源的所有lncRNA转录本（156个心脏样本和来自29个其他组织的210个样本），并系统分析了心脏中表达的所有带注释的和新颖的lncRNA。总共提取了在心脏中表达升高的7485个lncRNA（HE lncRNA）和在所有30个被分析的组织中表达的453个lncRNA（EIA lncRNA）。利用各种生物信息学资源，方法和工具，从各种角度讨论了这些lncRNA的特征，包括基因组结构，保守性，心脏发育过程中的动态变化，顺式调节，心血管疾病和癌症中的差异表达以及转录和转录后水平的调节。之后，以上讨论的所有功能都集成到名为CARDIO-LNCRNAS（http://bio-bigdata.hrbmu.edu.cn/CARDIO-LNCRNAS/或http://www.bio-bigdata.net / CARDIO-LNCRNAS /）。这项研究代表了基于多种组织的人类心血管系统中lncRNA的第一个全球视野，并阐明了lncRNA在发育和心脏疾病中的作用。心血管疾病和癌症中的差异表达，以及转录和转录后水平的调控。之后，以上讨论的所有功能都集成到名为CARDIO-LNCRNAS（http://bio-bigdata.hrbmu.edu.cn/CARDIO-LNCRNAS/或http://www.bio-bigdata.net / CARDIO-LNCRNAS /）。这项研究代表了基于多种组织的人类心血管系统中lncRNA的第一个全球视野，并阐明了lncRNA在发育和心脏疾病中的作用。心血管疾病和癌症中的差异表达，以及转录和转录后水平的调控。之后，以上讨论的所有功能都集成到名为CARDIO-LNCRNAS（http://bio-bigdata.hrbmu.edu.cn/CARDIO-LNCRNAS/或http://www.bio-bigdata.net / CARDIO-LNCRNAS /）。这项研究代表了基于多种组织的人类心血管系统中lncRNA的第一个全球视野，并阐明了lncRNA在发育和心脏疾病中的作用。