Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.

中文翻译：

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呼吸系统疾病中的氧化性和内质网应激。

氧化应激和内质网应激是相关状态，可以作为正常生理的一部分在细胞中发生，但在涉及炎症的疾病中经常发生。在本文中，我们回顾了有关氧化和内质网应激在急性和慢性非恶性肺部疾病（包括感染，囊性纤维化，特发性肺纤维化和哮喘）的病理生理中的作用的最新发现。我们还探讨了针对氧化和内质网应激途径的药物缓解疾病的潜力。