Degenerative disc disease (DDD) and osteoarthritis (OA) are relatively frequent causes of disability amongst the elderly; they constitute serious socioeconomic costs and significantly impair quality of life. Previous studies to date have found that aggrecan variable number of tandem repeats (VNTR) contributes both to DDD and OA. However, current data are not consistent across studies. The purpose of this study was to evaluate systematically the relationship between aggrecan VNTR, and DDD and/or OA.

中文翻译：

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聚集蛋白聚糖基因 VNTR 多态性分布与退行性椎间盘疾病/骨关节炎之间关系的系统评价。

退行性椎间盘疾病 (DDD) 和骨关节炎 (OA) 是老年人残疾的相对常见原因；它们构成严重的社会经济成本，严重损害生活质量。迄今为止的先前研究发现，聚集蛋白聚糖可变数量的串联重复 (VNTR) 对 DDD 和 OA 都有贡献。然而，目前的数据在各项研究中并不一致。本研究的目的是系统地评估聚集蛋白聚糖 VNTR 与 DDD 和/或 OA 之间的关系。