Unquestionably, the last six decades of research on various animal models have advanced our understanding of the mechanisms that underlie the many complex characteristics of amblyopia as well as provided promising new avenues for treatment. While animal models in general have served an important purpose, there nonetheless remain questions regarding the efficacy of particular models considering the differences across animal species, especially when the goal is to provide the foundations for human interventions. Our discussion of these issues culminated in three recommendations for future research to provide cohesion across animals models as well as a fourth recommendation for acceptance of a protocol for the minimum number of steps necessary for the translation of results obtained on particular animal models to human clinical trials. The three recommendations for future research arose from discussions of various issues including the specific results obtained from the use of different animal models, the degree of similarity to the human visual system, the ability to generate animal models of the different types of human amblyopia as well as the difficulty of scaling developmental timelines between different species.

中文翻译：

---

弱视动物模型

毫无疑问，过去 6 年对各种动物模型的研究加深了我们对弱视许多复杂特征背后的机制的理解，并为治疗提供了有希望的新途径。虽然动物模型通常具有重要目的，但考虑到动物物种之间的差异，特别是当目标是为人类干预提供基础时，关于特定模型的功效仍然存在问题。我们对这些问题的讨论最终形成了三项建议，为未来的研究提供跨动物模型的凝聚力，以及第四项建议，即接受将特定动物模型获得的结果转化为人体临床试验所需的最少步骤的协议.