Large-scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, making it a prototypical common disease with complex genetic architecture. Here, after a brief historical background on the discovery and definition of the disease, we summarise the last fifteen years of genetic discoveries and map out the challenges that remain to translate these findings into an aetiological framework and actionable clinical understanding.

中文翻译：

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多发性硬化症的全基因组关联研究。

多发性硬化症的大规模遗传研究已经确定了整个人类基因组的230多种风险效应，使其成为具有复杂遗传结构的典型常见疾病。在此，在简要介绍疾病发现和定义的历史背景之后，我们总结了遗传发现的最近十五年，并勾勒了将这些发现转化为病因学框架和可行的临床理解所面临的挑战。