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Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor.
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2018-04-17 , DOI: 10.2147/ijn.s155388
Shahid Mehmood 1 , Regina Ciancio 2 , Elvio Carlino 2, 3 , Arshad S Bhatti 1
Affiliation  

BACKGROUND The combination of Au-metallic-NPs and CNTs are a new class of hybrid nanomaterials for the development of electrochemical biosensor. Concentration of Au(nanoparticles [NPs]) in the electrochemical biosensor is crucial for the efficient charge transfer between the Au-NPs-MWCNTs modified electrode and electrolytic solution. METHODS In this work, the charge transfer kinetics in the glassy carbon electrode (GCE) modified with Au(NPs)-multiwalled carbon nanotube (MWCNT) nanohybrid with varied concentrations of Au(NPs) in the range 40-100 nM was studied using electrochemical impedance spectroscopy (EIS). Field emission scanning electron microscopy and transmission electron microscopy confirmed the attachment of Au(NPs) on the surface of MWCNTs. RESULTS The cyclic voltammetry and EIS results showed that the charge transfer mechanism was diffusion controlled and the rate of charge transfer was dependent on the concentration of Au(NPs) in the nanohybrid. The formation of spherical diffusion zone, which was dependent on the concentration of Au(NPs) in nanohybrids, was attributed to result in 3 times the increase in the charge transfer rate ks, 5 times increase in mass transfer, and 5% (9%) increase in Ipa (Ipc) observed in cyclic voltammetry in 80 nM Au(NP) nanohybrid-modified GCE from MWCNT-modified GCE. The work was extended to probe the effect of charge transfer rates at various concentrations of Au(NPs) in the nanohybrid-modified electrodes in the presence of Escherichia coli. The cyclic voltammetry results clearly showed the best results for 80 nM Au(NPs) in nanohybrid electrode. CONCLUSION The present study suggested that the formation of spherical diffusion zone in nanohybrid-modified electrodes is critical for the enhanced electrochemical biosensing applications.

中文翻译:

Au(NPs) 在 Au(NPs) 修饰的 MWCNT 电化学生物传感器增强响应中的作用。

背景技术Au-metallic-NPs和CNTs的结合是用于电化学生物传感器开发的一类新型混合纳米材料。电化学生物传感器中Au(纳米颗粒[NPs])的浓度对于Au-NPs-MWCNTs修饰电极和电解液之间的有效电荷转移至关重要。方法 在这项工作中,使用电化学方法研究了用 Au(NPs)-多壁碳纳米管 (MWCNT) 纳米杂化物修饰的玻碳电极 (GCE) 中的电荷转移动力学,其中 Au(NPs) 的浓度范围为 40-100 nM。阻抗谱(EIS)。场发射扫描电子显微镜和透射电子显微镜证实了 Au(NPs) 在 MWCNTs 表面的附着。结果循环伏安法和EIS结果表明,电荷转移机制是扩散控制的,电荷转移速率取决于纳米杂化物中Au(NPs)的浓度。球形扩散区的形成取决于纳米杂化物中 Au(NPs) 的浓度,这归因于电荷转移率 ks 增加 3 倍,传质增加 5 倍,以及 5% (9% ) 在来自 MWCNT 修饰的 GCE 的 80 nM Au(NP) 纳米杂化修饰的 GCE 中,在循环伏安法中观察到的 Ipa (Ipc) 增加。这项工作被扩展以探测在大肠杆菌存在下纳米杂化修饰电极中不同浓度的 Au(NPs) 的电荷转移率的影响。循环伏安法结果清楚地显示了纳米混合电极中 80 nM Au(NPs) 的最佳结果。
更新日期:2019-11-01
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