Blood clots occur in the human body when they are required to prevent bleeding. In pathological states such as diabetes and sickle cell disease, blood clots can also form undesirably due to hypercoagulable plasma conditions. With the continued effort in developing fibrin therapies for potential life-saving solutions, more mechanical modeling is needed to understand the properties of fibrin structures with inclusions. In this study, a fibrin matrix embedded with magnetic micro particles (MMPs) was subjected to a magnetic field to determine the magnitude of the required force to create plastic deformation within the fibrin clot. Using finite element (FE) analysis, we estimated the magnetic force from an electromagnet at a sample space located approximately 3[Formula: see text]cm away from the coil center. This electromagnetic force coupled with gravity was applied on a fibrin mechanical system with MMPs to calculate the stresses and displacements. Using appropriate coil parameters, it was determined that application of a magnetic field of 730[Formula: see text]A/m on the fibrin surface was necessary to achieve an electromagnetic force of 36[Formula: see text]nN (to engender plastic deformation).

中文翻译：

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嵌入微粒的纤维蛋白基质的电磁诱导畸变

当需要防止出血时，人体内会出现血栓。在诸如糖尿病和镰状细胞病等病理状态下，由于血浆高凝状态，血凝块也可能形成不希望的情况。随着为潜在的挽救生命的解决方案开发纤维蛋白疗法的持续努力，需要更多的机械建模来了解具有内含物的纤维蛋白结构的特性。在这项研究中，嵌入磁性微粒 (MMP) 的纤维蛋白基质经受磁场，以确定在纤维蛋白凝块内产生塑性变形所需的力的大小。使用有限元 (FE) 分析，我们在距线圈中心约 3 [公式：见文本] cm 的样本空间估计了来自电磁体的磁力。这种与重力耦合的电磁力被施加在具有 MMP 的纤维蛋白机械系统上，以计算应力和位移。使用适当的线圈参数，确定在纤维蛋白表面施加 730[公式：见文本]A/m 的磁场对于实现 36[公式：见文本]nN 的电磁力是必要的（以产生塑性变形）。