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Preparation of anticoagulant PyC biomaterials with super-hydrophobic surface
Journal of Applied Biomaterials & Functional Materials ( IF 2.5 ) Pub Date : 2018-01-01 , DOI: 10.1177/2280800017753315
Wang Ze 1 , Tan Wen-Sheng 2 , Ye-Xia 3 , Zhang Ming 1 , Li Xiao-Ping 1 , Qiu Jian-Guo 4 , Yang Xiao-Hong 1
Affiliation  

Introduction: Pyrolytic carbon (PyC) is a kind of biomaterial which is chemically inert and has excellent biocompatibility. In order to obtain a super-hydrophobic PyC surface to improve anticoagulation and inhibit thrombus, this study prepares grating pair structure, microhole array structure, helix structure on PyC surface by nanoseconds laser etching. Methods: Rod-like ZnO film and ball-like ZnO film are prepared on the PyC surface by the hydrothermal method; polyvinyl pyrrolidone (PVP) nanofiber film and PVP/TiO2 complex nanofiber film are prepared on the PyC surface by the electrospinning method; the PyC surface is silanized. Finally, surface microstructure and surface energy are characterized by scanning electron microscopy and contact angle meter (OCA20, German DataPhysics Co.). Results: The periodical microstructures are formed respectively by nanoseconds laser etching. The surface roughness is increased by the hydrothermal and electrospinning method. Conclusions: Through infiltration experiment on rough and smooth PyC surfaces, rough PyC surface with microstructure is super-hydrophobic and has greater than 150° contact angle, which decreases blood flow resistance and inhibits thrombus.

中文翻译:

具有超疏水表面的抗凝PyC生物材料的制备

简介: 热解碳(PyC)是一种化学惰性且具有优良生物相容性的生物材料。为了获得超疏水的PyC表面以提高抗凝和抑制血栓形成,本研究通过纳秒激光蚀刻在PyC表面制备了光栅对结构、微孔阵列结构、螺旋结构。方法:采用水热法在PyC表面制备棒状ZnO薄膜和球状ZnO薄膜;采用静电纺丝法在PyC表面制备聚乙烯吡咯烷酮(PVP)纳米纤维膜和PVP/TiO2复合纳米纤维膜;PyC 表面被硅烷化。最后,通过扫描电子显微镜和接触角仪(OCA20,德国DataPhysics Co.)表征表面微观结构和表面能。结果:周期性微结构分别通过纳秒激光蚀刻形成。通过水热和静电纺丝方法增加了表面粗糙度。结论:通过对粗糙和光滑 PyC 表面的渗透实验,具有微结构的粗糙 PyC 表面具有超疏水性,接触角大于 150°,降低了血流阻力,抑制了血栓形成。
更新日期:2018-01-01
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