This guideline is an update of the post-exposure prophylaxis (PEP) guideline published by the Southern African HIV Clinicians Society in 2008. It updates the recommendations on the use of antiretroviral medications to prevent individuals who have been exposed to a potential HIV source, via either occupational or non-occupational exposure, from becoming infected with HIV. No distinction is made between occupational or non-occupational exposure, and the guideline promotes the provision of PEP with three antiretroviral drugs if the exposure confers a significant transmission risk. The present guideline aligns with the principles of the World Health Organization PEP guidelines (2014), promoting simplification and adherence support to individuals receiving PEP.

中文翻译：

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关于人类免疫缺陷病毒职业和非职业接触管理的指南以及接触后预防的建议：2015年更新。

该指南是南部非洲HIV临床医师协会于2008年发布的暴露后预防（PEP）指南的更新。它更新了有关使用抗逆转录病毒药物以预防已暴露于潜在HIV感染源的个人的建议。无论是职业还是非职业接触，都被感染了艾滋病毒。职业暴露与非职业暴露之间没有区别，如果该暴露具有重大传播风险，则该指南将为PEP提供三种抗逆转录病毒药物。本指南符合世界卫生组织PEP指南（2014）的原则，为接受PEP的个人提供简化和依从性支持。