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Low blood lead levels and hemoglobin concentrations in preschool children in China
Toxicological & Environmental Chemistry ( IF 1.8 ) Pub Date : 2012-02-01 , DOI: 10.1080/02772248.2011.628001 Jianghong Liu 1 , Linda McCauley 2 , Chonghuai Yan 3 , Xiaoming Shen 3 , Jennifer A Pinto-Martin 1
Toxicological & Environmental Chemistry ( IF 1.8 ) Pub Date : 2012-02-01 , DOI: 10.1080/02772248.2011.628001 Jianghong Liu 1 , Linda McCauley 2 , Chonghuai Yan 3 , Xiaoming Shen 3 , Jennifer A Pinto-Martin 1
Affiliation
It is well known that lead (Pb) produces reduced haemoglobin (Hb) levels and risk of anemia when blood lead levels (BPb) are greater than 20 µg dL−1. Two recent studies reported an increased risk of anemia in children with BPb between 10–20 µg dL−1, but few studies examined the association between Hb levels or risk of anemia and BPb under 10 µg dL−1. In the present study this association was examined using data of 140 preschool children from a larger prospective cohort study in China. Data showed that compared to children with BPb <5 µg dL−1, children with BPb between 7.5–10 µg dL−1 had significantly lower Hb levels, but there were no marked differences for other groups. A linear regression model showed a negative relationship between BPb and Hb levels after controlling for age, gender, height, weight, and iron (Fe) deficiency. This finding, although limited by a small sample size, suggests it may be important to examine Pb-induced hemosynthesis effect at concentrations less than 10 µg dL−1.
更新日期：2012-02-01
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