BACKGROUND With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer's disease (AD). C-reactive protein (CRP) is a relatively stable peripheral inflammatory marker, but in previous studies the association between highly sensitive CRP (hsCRP) and AD have shown inconsistent results. This study examines the association between AD and hsCRP in blood samples taken up to 15 years prior to the diagnoses of 52 persons with AD amongst a total of 2150 persons ≥60 years of age. RESULTS Data from Norway's Nord-Trøndelag Health Study (HUNT 2) and the Health and Memory Study (HMS) were linked. The participants had an average age of 73 years, and diagnosed with AD up to 15 years [mean 8.0 (±3.9)] following hsCRP measurement. Logistic regression models showed an adverse association between hsCRP and AD in participants aged 60-70.5 (odds ratio: 2.37, 95% CI: 1.01-5.58). Conversely, in participants aged 70.6-94, there was an inverse association between hsCRP and AD (odds ratio: 0.39, 95% CI: 0.19-0.84). When applying multivariate models the findings were significant in individuals diagnosed 0.4-7 years after the hsCRP was measured; and attenuated when AD was diagnosed more than seven years following hsCRP measurement. CONCLUSIONS Our study is in line with previous studies indicating a shift in the association between hsCRP and AD by age: in adults (60-70.5 years) there is an adverse association, while in seniors (>70.6 years) there is an inverse association. If our findings can be replicated, a focus on why a more active peripheral immune response may have a protective role in individuals ≥70 years should be further examined.

中文翻译：

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60 岁及以上患者高敏 C 反应蛋白与阿尔茨海默病的关联：HUNT 研究，挪威。

背景技术随着年龄的增长，长期存在的炎症可能具有破坏性，导致多种疾病的发展，其中包括阿尔茨海默病(AD)。C 反应蛋白 (CRP) 是一种相对稳定的外周炎症标志物，但在以往的研究中，高度敏感的 CRP (hsCRP) 与 AD 之间的关联显示出不一致的结果。这项研究检查了在总共 2150 名 60 岁以上的人中，有 52 名患有 AD 的人在诊断前 15 年采集的血液样本中 AD 和 hsCRP 之间的关联。结果 挪威 Nord-Trøndelag 健康研究 (HUNT 2) 和健康与记忆研究 (HMS) 的数据相互关联。参与者的平均年龄为 73 岁，在 hsCRP 测量后被诊断患有 AD 长达 15 年 [平均 8.0 (±3.9)]。逻辑回归模型显示 hsCRP 和 AD 在 60-70.5 岁的参与者中存在负相关（优势比：2.37，95% CI：1.01-5.58）。相反，在 70.6-94 岁的参与者中，hsCRP 与 AD 之间存在负相关（优势比：0.39，95% CI：0.19-0.84）。当应用多变量模型时，在测量 hsCRP 后 0.4-7 年被诊断出的个体中的发现是显着的；在 hsCRP 测量后 7 年以上被诊断为 AD 时减弱。结论 我们的研究与先前的研究一致，表明 hsCRP 与 AD 之间的关联随年龄而变化：在成人（60-70.5 岁）中存在不利关联，而在老年人（>70.6 岁）中存在反向关联。如果我们的发现可以复制，