Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development.

中文翻译：

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老龄化：从炎症到癌症。

衰老是癌症发展的主要危险因素。衰老过程的标志是发炎，这是一种慢性和全身性的低度发炎过程。炎症也是癌症的标志，被广泛认为会影响从细胞转化到转移的所有癌症阶段。因此，发炎可能代表了能够将衰老过程与癌症发展相结合的生物学现象。在这里，我们回顾了与年龄相关的慢性炎症及其潜在触发因素及其与癌症发展的关系的分子和细胞途径。