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The effect of aminoguanidine (AG) and pyridoxamine (PM) on ageing human cortical bone.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2018-1-25 , DOI: 10.1302/2046-3758.71.bjr-2017-0135.r1
O Abar 1 , S Dharmar 2 , S Y Tang 3
Affiliation  

Advanced glycation end-products (AGEs) are a post-translational modification of collagen that form spontaneously in the skeletal matrix due to the presence of reducing sugars, such as glucose. The accumulation of AGEs leads to collagen cross-linking, which adversely affects bone quality and has been shown to play a major role in fracture risk. Thus, intervening in the formation and accumulation of AGEs may be a viable means of protecting bone quality.

中文翻译:

氨基胍(AG)和吡ido胺(PM)对衰老的人类皮质骨的影响。

高级糖基化终产物(AGEs)是胶原蛋白的翻译后修饰,由于存在还原糖(例如葡萄糖)而在骨骼骨架中自发形成。AGEs的积累导致胶原蛋白交联,这对骨质量产生不利影响,并已显示出在骨折风险中起主要作用。因此,干预AGEs的形成和积累可能是保护骨骼质量的可行方法。
更新日期:2020-08-21
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