Ribosomes are remarkable ribonucleoprotein complexes that are responsible for protein synthesis in all forms of life. They polymerize polypeptide chains programmed by nucleotide sequences in messenger RNA in a mechanism mediated by transfer RNA. One of the most challenging problems in the ribosome field is to understand the mechanism of coupled translocation of mRNA and tRNA during the elongation phase of protein synthesis. In recent years, the results of structural, biophysical and biochemical studies have provided extensive evidence that translocation is based on the structural dynamics of the ribosome itself. Detailed structural analysis has shown that ribosome dynamics, like aminoacyl-tRNA selection and catalysis of peptide bond formation, is made possible by the properties of ribosomal RNA.

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易位中的核糖体结构动力学：核糖体RNA的另一个功能作用

核糖体是非凡的核糖核蛋白复合物，负责所有生命形式的蛋白质合成。它们以转移 RNA 介导的机制聚合由信使 RNA 中的核苷酸序列编程的多肽链。核糖体领域最具挑战性的问题之一是了解蛋白质合成延伸阶段 mRNA 和 tRNA 耦合易位的机制。近年来，结构、生物物理和生化研究的结果提供了广泛的证据，表明易位是基于核糖体本身的结构动力学。详细的结构分析表明，核糖体动力学，如氨酰基-tRNA 选择和肽键形成的催化，是由核糖体 RNA 的特性实现的。