Most hormones display daily fluctuations of secretion during the 24-h cycle. This is also the case for adipokines, in particular the anorexigenic hormone, leptin. The temporal organization of the endocrine system is principally controlled by a network of circadian clocks. The circadian network comprises a master circadian clock, located in the suprachiasmatic nucleus of the hypothalamus, synchronized to the ambient light, and secondary circadian clocks found in various peripheral organs, such as the adipose tissues. Besides circadian clocks, other factors such as meals and metabolic status impact daily profiles of hormonal levels. In turn, the precise daily pattern of hormonal release provides temporal signaling information. This review will describe the reciprocal links between the circadian clocks and rhythmic secretion of leptin, and discuss the metabolic impact of circadian desynchronization and altered rhythmic leptin.

中文翻译：

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啮齿动物中脂肪因子调节的昼夜节律。

大多数激素在24小时周期内每天都会出现分泌波动。脂肪因子，特别是厌食激素瘦素也是如此。内分泌系统的时间结构主要由生物钟网络控制。该昼夜节律网络包括位于下丘脑上眼睑上核中并与环境光同步的主昼夜节律时钟，以及在诸如脂肪组织的各种外围器官中发现的次级昼夜节律时钟。除了昼夜节律，其他因素（例如进餐和代谢状态）也会影响荷尔蒙水平的日常状况。反过来，荷尔蒙释放的精确每日模式提供了时间信号信息。这篇评论将描述昼夜节律钟与瘦素节律性分泌之间的相互联系，