Growth hormone (GH) secretory patterns emerge following birth, and changes in patterning occur throughout life. These secretory patterns are coupled to growth, reproduction and metabolism. Comparing human and animal studies, this review will highlight ultradian patterning of GH release and the mechanisms that contribute to this. Discussions will focus on the emergence in variations in the number and frequency of GH secretory events, and the amounts of GH released (peak and basal). Animal studies have contributed significantly to our understanding of the processes that regulate GH release. However, translation of knowledge from animal models to benefit our understanding of human physiology is sometimes limited. To overcome these limitations, it is critical that we reconcile the cause and consequences of differences in GH release between humans and model organisms. In doing so, we can embrace emerging technologies that will rapidly advance our knowledge of endogenous process that control GH release.

中文翻译：

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生长激素释放的内分泌节律：动物研究的见解。

出生后会出现生长激素（GH）分泌模式，并且一生中都会发生模式变化。这些分泌模式与生长，繁殖和新陈代谢相关。比较人类和动物研究，本综述将重点介绍GH释放的超动物性模式及其促成作用的机制。讨论将集中在GH分泌事件的数量和频率变化以及GH释放量（峰值和基础）变化方面的出现。动物研究为我们对调节GH释放过程的理解做出了重要贡献。但是，从动物模型中获取知识以帮助我们理解人类生理的知识有时受到限制。为了克服这些限制，至关重要的是，我们必须调和人类与模型生物之间GH释放差异的原因和后果。这样，我们就可以接受新兴技术，这些技术将迅速提高我们对控制GH释放的内源性过程的了解。