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Triclosan exposure, transformation, and human health effects.
Journal of Toxicology and Environmental Health, Part B: Critical Reviews ( IF 7.2 ) Pub Date : 2017-11-29 , DOI: 10.1080/10937404.2017.1399306
Lisa M Weatherly 1, 2 , Julie A Gosse 1, 2
Affiliation  

Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the US Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. TCS is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems, was also summarized.

中文翻译:

三氯生的暴露,转化和对人类健康的影响。

三氯生(TCS)是一种普遍使用的抗菌剂,以致美国人口中有75%可能会通过消费品和个人护理产品而暴露于该化合物中。根据美国食品和药物管理局(FDA)的风险评估,2016年9月,TCS被禁止使用肥皂产品。但是,TCS仍以高浓度残留在其他个人护理产品中,例如牙膏,漱口水,洗手液和外科肥皂中。TCS容易被人体皮肤和口腔粘膜吸收,并存在于各种人体组织和体液中。这篇综述的目的是描述TCS的暴露途径和水平以及新陈代谢和转化过程。还总结了有关与TCS接触相关的人类健康影响(例如生殖问题)的新兴文献。
更新日期:2019-11-01
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