Recent technical advances in positron emission tomography/magnetic resonance imaging (PET/MRI) technology allow much improved time-of-flight (TOF) and regularized iterative PET reconstruction regularized iterative reconstruction (RIR) algorithms. We evaluated the effect of TOF and RIR on standardized uptake values (maximum and peak SUV [SUVmax and SUVpeak]) and their metabolic tumor volume dependencies and visual image quality for 18F-fluorocholine PET/MRI in patients with newly diagnosed prostate cancer. Fourteen patients were administered with 3 MBq/kg of 18F-fluorocholine and scanned dynamically for 30 minutes. Positron emission tomography images were divided to early and late time points (1-6 minutes summed and 7-30 minutes summed). The values of the different SUVs were documented for dominant PET-avid lesions, and metabolic tumor volume was estimated using a 50% isocontour and SUV threshold of 2.5. Image quality was assessed via visual acuity scoring (VAS). We found that incorporation of TOF or RIR increased lesion SUVs. The lesion to background ratio was not improved by TOF reconstruction, while RIR improved the lesion to background ratio significantly ( P < .05). The values of the different VAS were all significantly higher ( P < .05) for RIR images over TOF, RIR over non-TOF, and TOF over non-TOF. In conclusion, our data indicate that TOF or RIR should be incorporated into current protocols when available.

中文翻译：

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飞行时间和常规重建对18F-氟胆碱双时间点PET / MRI在新诊断的前列腺癌中定量测量和定性评估的影响。

正电子发射断层扫描/磁共振成像（PET / MRI）技术的最新技术进步允许大大改善飞行时间（TOF）和正则迭代PET重建正则化迭代重建（RIR）算法。我们评估了TOF和RIR对标准摄取值（最大和峰值SUV [SUVmax和SUVpeak]）及其对新诊断的前列腺癌患者的18F-氟胆碱PET / MRI的代谢肿瘤体积依赖性和视觉图像质量的影响。14名患者接受3 MBq / kg的18F-氟胆碱治疗，并动态扫描30分钟。将正电子发射断层扫描图像分为早期和晚期时间点（总计1-6分钟，总计7-30分钟）。记录了不同SUV的值，以显示PET占主导地位的病变，使用50％的等高线和SUV阈值为2.5估算代谢肿瘤的体积。通过视觉敏锐度评分（VAS）评估图像质量。我们发现掺入TOF或RIR会增加病变SUV。TOF重建并未改善病灶与背景的比率，而RIR显着改善了病灶与背景的比率（P <.05）。对于TOF之上的RIR图像，非TOF之上的RIR和非TOF之上的TOF，不同VAS的值均显着更高（P <.05）。总之，我们的数据表明TOF或RIR应该在可用的情况下并入当前协议中。TOF重建并未改善病灶与背景的比率，而RIR显着改善了病灶与背景的比率（P <.05）。对于TOF之上的RIR图像，非TOF之上的RIR和非TOF之上的TOF，不同VAS的值均显着更高（P <.05）。总而言之，我们的数据表明TOF或RIR应该在可用时并入当前协议中。TOF重建并未改善病灶与背景的比率，而RIR显着改善了病灶与背景的比率（P <.05）。对于TOF之上的RIR图像，非TOF之上的RIR和非TOF之上的TOF，不同VAS的值均显着更高（P <.05）。总而言之，我们的数据表明TOF或RIR应该在可用时并入当前协议中。