The cysteinyl leukotrienes (cysLTs) are proinflammatory lipid mediators that act on the type 1 cysLT receptor (CysLT1R) in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). GPR17, a G protein-coupled orphan receptor with homology to the cysLT receptors, has been proposed as a damage sensor during inflammation. However, the expression and correlation of GPR17 and CysLT1R in eosinophilic CRSwNP (ECRS) and non-eosinophilic CRSwNP (non-ECRS) have not been well investigated.

中文翻译：

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半胱氨酸白三烯受体GPR17在鼻息肉的嗜酸性和非嗜酸性慢性鼻-鼻窦炎中的表达。

半胱氨酰白三烯（cysLTs）是促炎性脂质介体，在慢性鼻鼻窦炎伴鼻息肉（CRSwNP）的发病机理中作用于1型cysLT受体（CysLT1R）。GPR17是一种与cysLT受体具有同源性的G蛋白偶联孤儿受体，已被提出作为炎症过程中的损伤传感器。但是，尚未对GPR17和CysLT1R在嗜酸性CRSwNP（ECRS）和非嗜酸性CRSwNP（non-ECRS）中的表达和相关性进行研究。