Stem cell delivery by local injection has tremendous potential as a regenerative therapy but has seen limited clinical success. Several mechanical challenges hinder therapeutic efficacy throughout all stages of cell transplantation, including mechanical forces during injection and loss of mechanical support post-injection. Recent studies have begun exploring the use of biomaterials, in particular hydrogels, to enhance stem cell transplantation by addressing the often-conflicting mechanical requirements associated with each stage of the transplantation process. This review explores recent biomaterial approaches to improve the therapeutic efficacy of stem cells delivered through local injection, with a focus on strategies that specifically address the mechanical challenges that result in cell death and/or limit therapeutic function throughout the stages of transplantation.

中文翻译：

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水凝胶力学在可注射干细胞移植中的不同作用。

通过局部注射递送干细胞作为再生疗法具有巨大的潜力，但临床成功率有限。在细胞移植的所有阶段中，一些机械难题阻碍了治疗功效，包括注射过程中的机械力和注射后失去机械支持。最近的研究已经开始探索使用生物材料，特别是水凝胶，通过解决与移植过程各个阶段相关的经常相互冲突的机械要求来增强干细胞移植。这篇评论探讨了最新的生物材料方法，以改善通过局部注射递送的干细胞的治疗功效，