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Fetal Tobacco Smoke Exposure in the Third Trimester of Pregnancy Is Associated with Atopic Eczema/Dermatitis Syndrome in Infancy.
Pediatric Allergy, Immunology, and Pulmonology ( IF 0.9 ) Pub Date : 2017-10-25 , DOI: 10.1089/ped.2017.0758
Miwa Shinohara 1, 2 , Kenji Matsumoto 3
Affiliation  

The manifestation of atopic dermatitis (AD) is initially nonatopic eczema in early infancy; the manifestations subsequently change in age-specific stages. Since allergen-specific T-helper 2 cells appear in the fetus primarily after the third trimester of pregnancy and rapidly mature during the first 6 months of life, different timings of tobacco smoke exposure may have different effects on AD. In this study, we investigated whether the timing of fetal or/and infantile tobacco smoke exposure affects the cumulative incidence of atopic eczema/dermatitis syndrome (AEDS) in infants in Japan. This cross-sectional study enrolled 1,177 parent-infant pairs, in which the infants were >6 months old. Parental allergic history, number of older siblings, physician-diagnosed AEDS and food allergy (FA), and the perinatal fetal and/or infantile tobacco smoke exposure timing after 28 weeks gestation and during the first 6 months of life were assessed using self-completed questionnaires. Fetal tobacco smoke exposure after 28 weeks gestation was significantly associated with higher cumulative incidence of AEDS in exposed infants than in unexposed infants: AEDS in all infants, 41.4% versus 34.0% (Chi-squared, P = 0.020; adjusted odds ratio, 5.21; 95% confidence interval, 1.08-25.15); AEDS in those without parental allergic history, 38.0% versus 26.6% (Chi-squared, P = 0.024). Postnatal infantile tobacco smoke exposure timing was not significantly associated with cumulative incidence of AEDS. No significant associations were observed between any tobacco smoke exposure timings and the cumulative incidence of FA. Fetal tobacco smoke exposure during the third trimester of pregnancy was positively associated with AEDS in infancy and might induce epigenetic changes in the fetal allergen-specific immune responses.

中文翻译:

孕晚期胎儿的烟尘暴露与婴儿特应性湿疹/皮炎综合症有关。

特应性皮炎的表现最初是婴儿早期的非特应性湿疹。这些表现随后在特定年龄阶段发生变化。由于过敏原特异的T-helper 2细胞主要在妊娠晚期开始出现在胎儿体内,并在生命的头6个月内迅速成熟,因此不同时间接触烟草烟雾可能对AD产生不同的影响。在这项研究中,我们调查了胎儿或/和婴儿烟草烟雾暴露的时间是否会影响日本婴儿特应性湿疹/皮炎综合症(AEDS)的累积发生率。这项横断面研究招募了1,177对父母-婴儿,其中婴儿的年龄大于6个月。父母的过敏史,年长的兄弟姐妹,医生诊断的AEDS和食物过敏(FA),并使用自我完成的调查问卷评估了妊娠28周后以及生命的头6个月中围产期胎儿和/或婴儿烟草烟雾的暴露时间。妊娠28周后胎儿烟气暴露与暴露婴儿相比,未暴露婴儿与更高的AEDS累积发生率显着相关:所有婴儿的AEDS分别为41.4%和34.0%(卡方,P = 0.020;调整后的优势比为5.21; 95%置信区间1.08-25.15);无父母过敏史者中的AEDS分别为38.0%和26.6%(卡方,P = 0.024)。出生后婴儿烟草烟雾暴露时间与AEDS累积发生率没有显着相关。在任何烟草烟雾暴露时间与FA的累积发生率之间均未发现显着关联。
更新日期:2019-11-01
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