Serotonin is a widely studied modulator of neural plasticity. Here we investigate the effect of fluoxetine, a selective serotonin reuptake inhibitor, on short-term, peripheral nociceptive plasticity in the neurologically complex invertebrate, octopus. After crush injury to isolated mantle (body wall) tissue, application of 10 nM fluoxetine increased spontaneous firing in crushed preparations, but had a minimal effect on mechanosensory sensitization. Effects largely did not persist after washout. We suggest that transiently elevated, endogenous serotonin may help promote initiation of longer-term plasticity of nociceptive afferents and drive immediate and spontaneous behaviors aimed at protecting wounds and escaping dangerous situations.

中文翻译：

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选择性5-羟色胺再摄取抑制剂氟西汀可增加章鱼的自发传入放电，但不增强机械感受性敏化作用。

5-羟色胺是广泛研究的神经可塑性调节剂。在这里，我们研究了氟西汀（一种选择性的5-羟色胺再摄取抑制剂）对神经系统复杂的无脊椎动物章鱼的短期，外周伤害性可塑性的影响。在对孤立的地幔（体壁）组织进行压伤后，在压碎的制剂中应用10 nM氟西汀可增加自发放电，但对机械感觉敏化的影响很小。冲洗后效果基本上没有持续。我们建议，短暂升高的内源性5-羟色胺可能有助于促进伤害性传入药物的长期可塑性启动，并推动旨在保护伤口和逃避危险情况的即时和自发行为。