The purpose of this study was to investigate the effects of Gelidium amansii (GA) hot-water extracts (GHE) on lipid metabolism in hamsters. Six-week-old male Syrian hamsters were used as the experimental animals. Hamsters were divided into four groups: (1) control diet group (CON); (2) high-fat diet group (HF); (3) HF with GHE diet group (HF + GHE); (4) HF with probucol diet group (HF + PO). All groups were fed the experimental diets and drinking water ad libitum for 6 weeks. The results showed that GHE significantly decreased body weight, liver weight, and adipose tissue (perirenal and paraepididymal) weight. The HF diet induced an increase in plasma triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol levels. However, GHE supplementation reversed the increase of plasma lipids caused by the HF diet. In addition, GHE increased fecal cholesterol, TG and bile acid excretion. Lower hepatic TC and TG levels were found with GHE treatment. GHE reduced hepatic sterol regulatory element-binding proteins (SREBP) including SREBP 1 and SREBP 2 protein expressions. The phosphorylation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) protein expression in hamsters was decreased by the HF diet; however, GHE supplementation increased the phosphorylation of AMPK protein expression. Our results suggest that GHE may ameliorate lipid metabolism in hamsters fed a HF diet.

中文翻译：

---

红藻 (Gelidium amansii) 热水提取物改善高脂饮食仓鼠的脂质代谢

本研究的目的是研究石花子 (GA) 热水提取物 (GHE) 对仓鼠脂质代谢的影响。以六周大的雄性叙利亚仓鼠为实验动物。仓鼠分为四组：（1）控制饮食组（CON）；（2）高脂饮食组（HF）；(3) HF 与 GHE 饮食组 (HF + GHE)；(4) HF加普罗布考饮食组(HF+PO)。所有组均喂食实验饮食和饮用水，持续 6 周。结果表明，GHE 显着降低了体重、肝脏重量和脂肪组织（肾周和附睾旁）重量。HF 饮食导致血浆三酰基甘油 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平升高。然而，GHE 补充剂逆转了由 HF 饮食引起的血浆脂质增加。此外，GHE 增加粪便胆固醇、TG 和胆汁酸排泄。GHE 治疗后发现肝脏 TC 和 TG 水平降低。GHE 降低肝甾醇调节元件结合蛋白 (SREBP)，包括 SREBP 1 和 SREBP 2 蛋白表达。HF 饮食降低了仓鼠中一磷酸腺苷 (AMP) 活化蛋白激酶 (AMPK) 蛋白表达的磷酸化；然而，GHE 补充剂增加了 AMPK 蛋白表达的磷酸化。我们的研究结果表明，GHE 可以改善喂食 HF 饮食的仓鼠的脂质代谢。GHE 降低肝甾醇调节元件结合蛋白 (SREBP)，包括 SREBP 1 和 SREBP 2 蛋白表达。HF 饮食降低了仓鼠中一磷酸腺苷 (AMP) 活化蛋白激酶 (AMPK) 蛋白表达的磷酸化；然而，GHE 补充剂增加了 AMPK 蛋白表达的磷酸化。我们的研究结果表明，GHE 可以改善喂食 HF 饮食的仓鼠的脂质代谢。GHE 降低肝甾醇调节元件结合蛋白 (SREBP)，包括 SREBP 1 和 SREBP 2 蛋白表达。HF 饮食降低了仓鼠中一磷酸腺苷 (AMP) 活化蛋白激酶 (AMPK) 蛋白表达的磷酸化；然而，GHE 补充剂增加了 AMPK 蛋白表达的磷酸化。我们的研究结果表明，GHE 可以改善喂食 HF 饮食的仓鼠的脂质代谢。