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Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.
Human Heredity ( IF 1.8 ) Pub Date : 2017-09-15 , DOI: 10.1159/000478897
Jonathan T L Kang 1 , Amy Goldberg , Michael D Edge , Doron M Behar , Noah A Rosenberg
Affiliation  

OBJECTIVES Recent studies have highlighted the potential of analyses of genomic sharing to produce insight into the demographic processes affecting human populations. We study runs of homozygosity (ROH) in 18 Jewish populations, examining these groups in relation to 123 non-Jewish populations sampled worldwide. METHODS By sorting ROH into 3 length classes (short, intermediate, and long), we evaluate the impact of demographic processes on genomic patterns in Jewish populations. RESULTS We find that the portion of the genome appearing in long ROH - the length class most directly related to recent consanguinity - closely accords with data gathered from interviews during the 1950s on frequencies of consanguineous unions in various Jewish groups. CONCLUSION The high correlation between 1950s consanguinity levels and coverage by long ROH explains differences across populations in ROH patterns. The dissection of ROH into length classes and the comparison to consanguinity data assist in understanding a number of additional phenomena, including similarities of Jewish populations to Middle Eastern, European, and Central and South Asian non-Jewish populations in short ROH patterns, relative lengths of identity-by-descent tracts in different Jewish groups, and the "population isolate" status of the Ashkenazi Jews.

中文翻译:

血缘关系率预测犹太人群体的长期纯合性。

目的最近的研究强调了基因组共享分析的潜力,可以深入了解影响人口的人口统计过程。我们研究了18个犹太人口的纯合性(ROH)运行情况,并与全球123个非犹太人口的样本进行了比较。方法通过将ROH分为3个长度类别(短,中和长),我们评估了人口统计学过程对犹太人群基因组模式的影响。结果我们发现,出现在长ROH中的基因组部分-与最近血缘关系最直接的长度类别-与1950年代在各个犹太人群中血缘结合频率的采访中收集的数据非常吻合。结论1950年代血缘水平与长期ROH覆盖率之间的高度相关性说明了ROH模式在人群之间的差异。将ROH分为长度类别和与血缘关系数据进行比较有助于理解许多其他现象,包括犹太人与ROH短模式下的中东,欧洲,中亚和南亚非犹太人口的相似性,相对长度不同犹太群体的血统身份,以及阿什肯纳兹犹太人的“人口隔离”身份。
更新日期:2019-11-01
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