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Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries.
Acta Microbiologica et Immunologica Hungarica ( IF 1.5 ) Pub Date : 2017-09-11 , DOI: 10.1556/030.64.2017.033
Sajith Vellappally 1 , Darshan Devang Divakar 1, 2 , Abdulaziz Abdullah Al Kheraif 1 , Ravikumar Ramakrishnaiah 1 , Amer Alqahtani 3 , M H N Dalati 4 , Sukumaran Anil 5 , Aftab Ahmed Khan 1 , P R Harikrishna Varma 6
Affiliation  

Oral streptococci are the major group of microbes isolated from oral microflora. They represent frequent pathogens of infective endocarditis (IE), and it is assumed that in most of the cases oral streptococci are acquired via mucosa layer of oral cavity. Staphylococcus aureus is also frequently isolated from IE as it accounts for 20%-30% of all cases. Vancomycin has been the most reliable therapeutic agent against infections caused by methicillin-resistant S. aureus (MRSA). The main objective of this study was to examine the occurrence of S. aureus species in dental caries specimens. Antimicrobial susceptibility testing of S. aureus to four antibiotics namely vancomycin, linezolid, teicoplanin, and daptomycin was performed. Detection of vancomycin resistance was conducted using polymerase chain reaction. Among the tested 150 strains, 98 were MRSA and of that 54 were vancomycin sensitive and 27 were resistant. All 98 MRSA strains were positive for mecA and 36 yielded pvl, whereas 13 carried vanA and only 2 were positive for vanB. Majority of the isolates showed sensitivity toward daptomycin and linezolid. Strains of S. aureus exhibiting decreased susceptibility to different antibiotics like vancomycin, daptomycin, and linezolid severely compromise the therapeutic alternatives and require a considerable amount of time, public awareness, and integrative health-care strategies to prevent the emergence of resistance to these compounds.

中文翻译:

龋齿患者口腔中出现耐万古霉素金黄色葡萄球菌。

口腔链球菌是从口腔菌群中分离出的主要微生物。它们代表感染性心内膜炎(IE)的常见病原体,并且假定在大多数情况下,口腔链球菌是通过口腔粘膜层获得的。金黄色葡萄球菌也经常从IE中分离出来,因为它占所有病例的20%-30%。万古霉素一直是最可靠的抗甲氧西林金黄色葡萄球菌(MRSA)感染的治疗剂。这项研究的主要目的是检查龋齿标本中金黄色葡萄球菌的种类。进行了金黄色葡萄球菌对四种抗生素万古霉素,利奈唑胺,替考拉宁和达托霉素的药敏试验。使用聚合酶链反应进行万古霉素抗性的检测。在测试的150个菌株中,MRSA 98例,对万古霉素敏感54例,耐药27例。所有98株MRSA菌株均对mecA呈阳性,其中36株产生pvl,而13株携带vanA,只有2株对vanB呈阳性。大多数分离株显示对达托霉素和利奈唑胺敏感。金黄色葡萄球菌对万古霉素,达托霉素和利奈唑胺等不同抗生素的敏感性降低,严重影响了治疗选择,并需要大量时间,公众意识和综合保健策略,以防止出现对这些化合物的耐药性。大多数分离株显示对达托霉素和利奈唑胺敏感。金黄色葡萄球菌对万古霉素,达托霉素和利奈唑胺等不同抗生素的敏感性降低,严重影响了治疗选择,并需要大量时间,公众意识和综合保健策略,以防止出现对这些化合物的耐药性。大多数分离株显示对达托霉素和利奈唑胺敏感。金黄色葡萄球菌对万古霉素,达托霉素和利奈唑胺等不同抗生素的敏感性降低,严重影响了治疗选择,并需要大量时间,公众意识和综合保健策略,以防止出现对这些化合物的耐药性。
更新日期:2020-08-21
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