CRISPR-Cas9 has emerged as a simple, precise and most rapid genome editing technology. With a number of promising applications ranging from agriculture and environment to clinical therapeutics, it is greatly transforming the field of molecular biology. However, there are certain ethical, moral and safety concerns related to the attractive applications of this technique. The most contentious issues concerning human germline modifications are the challenges to human safety and morality such as risk of unforeseen, undesirable effects in clinical applications particularly to correct or prevent genetic diseases, matter of informed consent and the risk of exploitation for eugenics. Stringent regulations and guidelines as well as worldwide debate and awareness are required to ensure responsible and wise use of CRISPR mediated genome editing technology. There is a need for an extensive dialogue among scientists, ethicists, industrialists and policy makers on its societal implications. The opinion of different elements of the society including the general public as well as religious scholars is also critical. In countries with existing legislative framework, it might be appropriate to allow CRISPR based research to proceed with proper justification. However, much anticipated future clinical applications must be strictly regulated with newly established regulations.

中文翻译：

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关于 CRISPR 介导的基因组编辑的伦理问题。

CRISPR-Cas9 已成为一种简单、精确和最快速的基因组编辑技术。从农业和环境到临床治疗，它具有许多有前景的应用，正在极大地改变分子生物学领域。然而，与该技术的有吸引力的应用相关的某些伦理、道德和安全问题。关于人类生殖系修饰最有争议的问题是对人类安全和道德的挑战，例如临床应用中不可预见的、不良影响的风险，特别是纠正或预防遗传疾病、知情同意问题和优生学被利用的风险。为了确保负责任和明智地使用 CRISPR 介导的基因组编辑技术，需要严格的法规和指导方针以及全球范围内的辩论和认识。科学家、伦理学家、工业家和政策制定者之间需要就其社会影响进行广泛对话。包括公众和宗教学者在内的社会不同阶层的意见也很重要。在具有现有立法框架的国家，允许基于 CRISPR 的研究以适当的理由进行可能是合适的。然而，备受期待的未来临床应用必须受到新制定的法规的严格监管。允许基于 CRISPR 的研究以适当的理由进行可能是合适的。然而，备受期待的未来临床应用必须受到新制定的法规的严格监管。允许基于 CRISPR 的研究以适当的理由进行可能是合适的。然而，备受期待的未来临床应用必须受到新制定的法规的严格监管。