Pulmonary artery hypertension is a syndrome that shows similar clinical and pathophysiological features characterized by elevated pulmonary arterial pressure and resistance. There have been a series of hypotheses trying to describe the development of pulmonary artery hypertension; however, none of them perfectly explains its pathogenesis. To highlight the pathogenesis, novel vasomotorial cytokines including hypoxia-inducible factor-1α, endothelin-1, urotensin II, Krüppel-like factor 4, calcitonin gene-related peptide, angiopoietins and serotonin closely related to pulmonary artery hypertension are discussed. The development of the new agents relating to these cytokines may improve the relevant treatment strategies.

中文翻译：

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肺动脉高压：相关的血管内皮细胞因子。

肺动脉高压是一种表现出相似的临床和病理生理特征的综合征，其特征是肺动脉压和抵抗力升高。有一系列假说试图描述肺动脉高压的发展。然而，它们都不能完美地解释其发病机理。为了突出发病机理，讨论了与低氧诱导因子-1α，内皮素-1，尿紧张素II，Krüppel样因子4，降钙素基因相关肽，血管生成素和5-羟色胺密切相关的新型血管内皮细胞因子。与这些细胞因子有关的新药物的开发可能会改善相关的治疗策略。