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The effect of scopolamine on matching behavior and the estimation of relative reward magnitude.
Behavioral Neuroscience ( IF 1.9 ) Pub Date : 2017-08-14 , DOI: 10.1037/bne0000213
Matthew I Leon 1 , Vanessa Rodriguez-Barrera 1 , Aldo Amaya 1
Affiliation  

We investigated the behavioral effects of scopolamine on rats that bar pressed for trains of electrically stimulating pulses under concurrent variable interval schedules of reward. For the first half of the session (30 min) a 1:4 ratio in the programmed number of stimulation trains delivered at each option was in effect. At the start of the second half of the session, an unsignaled reversal in the relative train number (4:1) occurred. We tracked the relative magnitude of reward estimated for each contiguous pair of reinforced visits to competing options. Scopolamine hydrobromide led to a reduction in the relative magnitude of reward. A similar result was obtained in a follow-up test in which relative magnitude was manipulated by varying the pulse frequency of stimulation, while equating the train number at each option. The effect of scopolamine hydrobromide could not be attributed to undermatching, side bias, nor to an effect of scopolamine on the reward integration process. When the same rats were treated with scopolamine methylbromide, no effects on matching behavior were observed. Our results suggest a cholinergic basis for the computation of choice variables related to matching behavior. (PsycINFO Database Record

中文翻译:

东pol碱对配偶行为的影响和相对奖励幅度的估计。

我们调查了东pol碱对大鼠的行为影响,该大鼠在并发的可变间隔奖励计划下压制电刺激脉冲序列。在训练的前半部分(30分钟)中,在每个选项下传递的刺激程序的编程数量中的1:4比例有效。在下半场开始时,相对列车编号(4:1)发生了无信号的反转。我们跟踪了对竞争性选择的每对连续访问的估计的相对奖励幅度。氢溴酸东pol碱导致奖励的相对幅度降低。在后续测试中获得了类似的结果,在该测试中,通过改变刺激的脉冲频率来操纵相对幅度,同时使每个选项的列车编号相等。东pol碱氢溴酸盐的作用不能归因于配比不足,侧偏,也不能归因于东pol碱对奖励积分过程的影响。用东rats碱甲基溴治疗相同的大鼠时,未观察到对匹配行为的影响。我们的结果为计算与匹配行为相关的选择变量提供了胆碱能基础。(PsycINFO数据库记录
更新日期:2020-08-21
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