Using gold nanoparticle-templated high-density lipoprotein-like particles as a model, the nanoparticle-templated phospholipid bilayer is studied from the bottom-up. Data support the phospholipids have a mosaic interdigitated structure. The discontinuous lipid milieu supports partial lipidation of apolipoprotein A-I, different from an ordinary phospholipid bilayer, suggesting that synergy between nanoparticle templates and bound phospholipid layers can modulate amphiphilic proteins for desired functions.

中文翻译：

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纳米颗粒模板化磷脂双层中的镶嵌交叉结构支持载脂蛋白 AI 的部分脂质化

以金纳米颗粒为模板的高密度脂蛋白样颗粒为模型，自下而上地研究了以纳米颗粒为模板的磷脂双层。数据支持磷脂具有镶嵌交叉结构。不连续的脂质环境支持载脂蛋白 AI 的部分脂化，这与普通的磷脂双层不同，这表明纳米颗粒模板和结合的磷脂层之间的协同作用可以调节两亲蛋白以实现所需的功能。