Fatigue and low energy are cardinal symptoms of major depressive disorder (MDD) that have an impact on work functioning. Antidepressants with noradrenergic activity have been hypothesized to improve symptoms of fatigue and low energy. We examined the impact of these symptoms on work functioning in patients with MDD treated with the serotonin and noradrenaline reuptake inhibitor, desvenlafaxine. A secondary analysis was carried out from a study of employed adult outpatients (n=35) with MDD and subjective cognitive complaints treated with desvenlafaxine 50-100 mg/day for 8 weeks. Multiple regression analyses modeled improvement in work functioning measures (Lam Employment Absence and Productivity Scale, Health and Work Performance Questionnaire, Sheehan Disability Scale) with measures of fatigue (Patient-Reported Outcomes Measurement Information System Fatigue scale and 20-item Hopkins Symptom Check List Energy scale). Patients showed a significant improvement in Montgomery-Åsberg Depression Rating Scale scores as well as in fatigue and work functioning measures following treatment. Fatigue measures were significantly associated with improvement in some (Lam Employment Absence and Productivity Scale, Sheehan Disability Scale), but not all (Health and Work Performance Questionnaire) work functioning measures, independent of improvement in overall depressive symptoms. The limitations of this study include the small sample size and the lack of a placebo or a comparison group. Fatigue and low energy are important symptoms that are associated with occupational impairment in MDD. Treatments that improve these symptoms are likely to improve work functioning.

中文翻译：

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疲劳和精力对使用去甲文拉法辛治疗的重度抑郁症患者工作功能和功能障碍的影响。

疲劳和低能量是重度抑郁症（MDD）的主要症状，对工作功能有影响。假设具有降肾上腺素能活性的抗抑郁药可改善疲劳和低能量症状。我们检查了这些症状对使用5-羟色胺和去甲肾上腺素再摄取抑制剂地沙文拉法辛治疗的MDD患者工作功能的影响。一项次要分析是对一项接受MDD治疗的成人门诊患者（n = 35）和主观认知障碍的研究进行的，该患者接受地韦拉法辛50-100 mg /天治疗8周。多元回归分析建立了工作功能指标改善的模型（Lam缺勤和生产率量表，健康和工作绩效调查表，希恩（Sheehan）伤残量表）和疲劳量度（患者报告的结果测量信息系统疲劳量表和20项霍普金斯症状检查表能量量表）。患者在蒙哥马利-奥斯伯格抑郁量表评分以及治疗后的疲劳和工作功能指标方面均取得了显着改善。疲劳措施与某些（Lam就业缺勤和生产力量表，Sheehan残疾量表）的改善显着相关，但并非所有（健康和工作绩效问卷）工作功能量的改善均与改善整体抑郁症状无关。这项研究的局限性包括样本量小，缺乏安慰剂或对照组。疲劳和低能量是与MDD职业损伤相关的重要症状。