Stem cells undergo extensive metabolic rewiring during reprogramming, proliferation and differentiation, and numerous studies have demonstrated a significant role of metabolism in controlling stem cell fates. Recent applications of metabolomics, the study of concentrations and fluxes of small molecules in cells, have advanced efforts to characterize and maturate stem cell fates, assess drug toxicity in stem cell tissue models, identify biomarkers, and study the effects of environment on metabolic pathways in stem cells and their progeny. Looking to the future, combining metabolomics with other -omics approaches will provide a deeper understanding of the complex regulatory mechanisms of stem cells.

中文翻译：

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代谢组学在多能干细胞研究中的应用进展。

干细胞在重编程、增殖和分化过程中经历广泛的代谢重连，大量研究表明代谢在控制干细胞命运中发挥着重要作用。代谢组学的最新应用，即细胞中小分子的浓度和通量的研究，在表征和成熟干细胞命运、评估干细胞组织模型中的药物毒性、识别生物标志物以及研究环境对代谢途径的影响方面取得了进展。干细胞及其后代。展望未来，将代谢组学与其他组学方法相结合将有助于更深入地了解干细胞的复杂调控机制。