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Recent advances in gossypol derivatives and analogs: a chemistry and biology view.
Future Medicinal Chemistry ( IF 4.2 ) Pub Date : 2017-07-20 , DOI: 10.4155/fmc-2017-0046
Yuzhi Lu 1 , Jun Li 1 , Chun-E Dong 1 , Jian Huang 2 , Hai-Bing Zhou 1 , Wei Wang 1
Affiliation  

Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic contexts for a long time. The chemical modifications on gossypol were limited due to the unique chemical properties of polyphenols. The design and synthesis of gossypol derivatives and the exploration of their biological activities are the interest of the synthetic chemists, medicinal chemists and pharmacologists. Thus, the progress of diverse gossypol derivatives and analogs' synthesis, biological activities, mechanism elucidation and drug discovery based on gossypol scaffold is summarized.

中文翻译:

棉酚衍生物和类似物的最新进展:化学和生物学观点。

棉酚作为一种天然存在的多酚,已经在广泛的治疗环境中进行了长期的研究。由于多酚的独特化学性质,棉酚上的化学修饰受到限制。棉酚衍生物的设计和合成以及其生物学活性的探索是合成化学家,药物化学家和药理学家的兴趣。因此,总结了基于棉酚骨架的多种棉酚衍生物及其类似物的合成,生物学活性,机理阐明和药物发现的进展。
更新日期:2019-11-01
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