BACKGROUND Antimicrobial resistant Salmonella strains are a direct threat to human health when this resistance interferes with treatment and an indirect threat when resistance can be transferred to other human pathogens. The objective of the present study was to characterize antimicrobial resistant non-typhoidal Salmonella (NTS) isolates recovered from poultry industries, including a description of genetic diversity and virulence profiles. RESULTS In total of 93 Salmonella isolates shown antimicrobial resistance to one or more drugs, all isolates exhibited common resistance to streptomycin, nalidixic acid and cephalothin but no ciprofloxacin resistance. Among 26 virulence gene profiling, 12 virulence genes, invA, orgA, prgH, sopB, tolC, sipB, gatC, msgA, pagC, spiA, sifA, and sitC were found in all antimicrobial-resistant NTS isolates. In comparing the data from ERIC-PCR clusters, virulence profiles and resistance profiles, some Salmonella isolates grouped into the same cluster were found to exhibit similar virulence and resistance patterns. CONCLUSIONS Virulence profiling combined with ERIC-PCR offered a rapid approach to characterize antimicrobial-resistant NTS.

中文翻译：

---

来自韩国家禽业的抗菌素耐药性非伤寒沙门氏菌的分子表征。

背景技术抗药性沙门氏菌菌株在这种抗性干扰治疗时是对人类健康的直接威胁，而在抗性可以转移到其他人类病原体时则是间接威胁。本研究的目的是鉴定从家禽业中回收的抗菌素耐药性非伤寒沙门氏菌（NTS）分离株，包括遗传多样性和毒力概况的描述。结果总共93株沙门氏菌对一种或多种药物表现出抗药性，所有分离物均对链霉素，萘啶酸和头孢菌素具有共同的耐药性，但对环丙沙星没有耐药性。在26种毒力基因分析中，在所有抗药性NTS分离物中均发现了12种毒力基因，分别是invA，orgA，prgH，sopB，tolC，sipB，gatC，msgA，pagC，spiA，sifA和sitC。在比较来自ERIC-PCR簇，毒力谱和抗药性谱的数据时，发现一些归入同一簇的沙门氏菌分离株表现出相似的毒力和抗性模式。结论毒力谱分析结合ERIC-PCR提供了一种快速的方法来表征抗药性NTS。