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Photobiomodulation and the brain: a new paradigm
Journal of Optics ( IF 2.1 ) Pub Date : 2016-12-14 , DOI: 10.1088/2040-8986/19/1/013003
Madison Hennessy 1 , Michael R Hamblin 2, 3, 4
Affiliation  

Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondria (cytochrome c oxidase), and ion channels in cells leading to activation of signaling pathways, up-regulation of transcription factors, and increased expression of protective genes. We have studied PBM for treating traumatic brain injury (TBI) in mice using a NIR laser spot delivered to the head. Mice had improved memory and learning, increased neuroprogenitor cells in the dentate gyrus and subventricular zone, increased BDNF and more synaptogenesis in the cortex. These highly beneficial effects on the brain suggest that the applications of tLLLT are much broader than at first conceived. Other groups have studied stroke (animal models and clinical trials), Alzheimer's disease, Parkinson's disease, depression, and cognitive enhancement in healthy subjects.

中文翻译:

光生物调节和大脑:一种新范式

经颅光生物调节 (PBM) 也称为低强度激光疗法 (tLLLT),它依赖于使用红光/近红外光来刺激、保存和再生细胞和组织。作用机制涉及线粒体中的光子吸收(细胞色素 c 氧化酶)和细胞中的离子通道,导致信号通路激活、转录因子上调和保护基因表达增加。我们研究了 PBM 用于使用传递到头部的 NIR 激光点治疗小鼠的外伤性脑损伤 (TBI)。小鼠的记忆力和学习能力得到改善,齿状回和脑室下区的神经祖细胞增加,BDNF 增加,皮质中的突触发生增多。这些对大脑非常有益的影响表明 tLLLT 的应用比最初设想的要广泛得多。
更新日期:2016-12-14
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