Dopamine D2-receptor blockade by antipsychotic medication reduces psychotic symptoms, but may reduce subjective well-being. The current study aims to further explore the relation between dopamine D2-receptor affinity and subjective well-being within a large sample of patients with psychotic disorders. Patients participated in a longitudinal naturalistic cohort study: the Genetic Risk and Outcome of Psychosis (GROUP) study. Three groups of antipsychotic medication were created on the basis of their affinity for the D2-receptor: (i) loose or partial agonistic binding, (ii) moderate binding, and (iii) tight binding. Subjective well-being was assessed using the Subjective Well-being under Neuroleptics scale (SWN) at baseline and the 3-year follow-up. In addition, we compared changes in SWN scores when switching to a more 'loose or partial agonistic' binding agent or to a 'tighter' binding agent between baseline and the 3-year follow-up. The final group included 388 patients at baseline and 290 at the 3-year follow-up. No significant differences in the SWN scores were found between the three affinity groups at baseline and the 3-year follow-up. In addition, analyses yielded no significant changes in SWN scores after switching to a more 'loose or partial agonistic' or more 'tight' binding antipsychotic agent. We did not find further support for the hypothesis that subjective well-being is associated with antipsychotics affinity for dopamine D2-receptors. This might imply that the effect of antipsychotic D2-receptors binding on subjective well-being is not large enough to be detected in this cross-sectional study. Other factors besides dopamine antagonism are probably more relevant for subjective well-being.

中文翻译：

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抗精神病药的多巴胺D2受体亲和力与精神病患者的主观幸福感有关。

抗精神病药对多巴胺D2受体的阻滞可减轻精神病症状，但可能会降低主观幸福感。当前的研究旨在进一步探索大量精神病患者样本中多巴胺D2受体亲和力与主观幸福感之间的关系。患者参加了一项纵向自然队列研究：精神病的遗传风险和结果（GROUP）研究。根据三类抗精神病药物对D2受体的亲和力，创建了三组抗精神病药物：（i）松散或部分激动性结合，（ii）中度结合，和（iii）紧密结合。在基线和3年的随访中，使用抗精神病药的主观幸福感量表（SWN）评估主观幸福感。此外，我们比较了切换到更多“ 在基线和3年随访之间，使用松散或部分激动的“粘合剂”或“更紧密”的粘合剂。最后一组在基线时包括388名患者，在3年的随访中包括290名患者。在基线和3年随访时，三个亲和力组之间的SWN得分无明显差异。此外，在转换为更具“松散性或部分激动性”或更具有“紧密性”的结合抗精神病药后，分析未产生SWN分数的显着变化。对于主观幸福感与多巴胺D2受体的抗精神病药亲和力相关的假设，我们没有找到进一步的支持。这可能暗示抗精神病药D2受体结合对主观幸福感的影响不够大，无法在此横断面研究中检测到。