Human papillomaviruses (HPV) infect and replicate in stratified epithelium at cutaneous and mucosal surfaces. The proliferation and maintenance of keratinocytes, the cells which make up this epithelium, are controlled by a number of growth factor receptors such as the keratinocyte growth factor receptor (KGFR, also called fibroblast growth factor receptor 2b (FGFR2b)), the epithelial growth factor receptor (EGFR) and the insulin-like growth factor receptors 1 and 2 (IGF1R and IGF2R). In this review, we will delineate the mutation, gene transcription, translation and processing of the IGF axis within HPV associated cancers. The IGFs are key for developmental and postnatal growth of almost all tissues; we explore whether this crucial axis has been hijacked by HPV.

中文翻译：

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HPV相关癌症中的IGF轴。

人乳头瘤病毒（HPV）感染并在皮肤和粘膜表面的分层上皮细胞中复制。构成该上皮的细胞角质形成细胞的增殖和维持受到许多生长因子受体的控制，例如角质形成细胞生长因子受体（KGFR，也称为成纤维细胞生长因子受体2b（FGFR2b）），上皮生长因子受体（EGFR）和胰岛素样生长因子受体1和2（IGF1R和IGF2R）。在这篇综述中，我们将描述与HPV相关的癌症中IGF轴的突变，基因转录，翻译和加工。IGF是几乎所有组织发育和出生后生长的关键。我们探讨了HPV是否劫持了这一关键轴。