Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.

中文翻译：

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Laron综合征患者的IGF-I缺乏症，寿命和癌症保护。

Laron综合征（LS）是先天性IGF-I缺乏症的独特模型。它的特征是侏儒症和肥胖症，并且是由生长激素受体（GH-R）基因的缺失或突变引起的。据推测，LS是起源于印度尼西亚的一种古老疾病，该突变基因传播到南亚，中东，地中海地区和南美。