Since its conceptualization in the 1980s, the provisional matrix has often been characterized as a simple fibrin-containing scaffold for wound healing that supports the nascent blood clot and is functionally distinct from the basement membrane. However subsequent advances have shown that this matrix is far from passive, with distinct compositional differences as the wound matures, and providing an active role for wound remodeling. Here we review the stages of this matrix, provide an update on the state of our understanding of provisional matrix, and present some of the outstanding issues related to the provisional matrix, its components, and their assembly and use in vivo.

中文翻译：

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临时矩阵：为组织修复结果奠定基础。

自从1980年代概念化以来，临时基质通常被表征为用于伤口愈合的简单的含纤维蛋白支架，该支架支持新生的血凝块，并且在功能上不同于基底膜。然而，随后的进展表明，该基质远非被动的，随着伤口的成熟，其成分明显不同，并为伤口重塑提供了积极的作用。在这里，我们回顾了此矩阵的各个阶段，提供了对我们对临时矩阵的了解的最新状态，并提出了一些与临时矩阵，其组成及其在体内的组装和使用有关的悬而未决的问题。