The role of substrate mechanics in guiding mesenchymal stem cell (MSC) fate has been the focus of much research over the last decade. More recently, the complex interplay between substrate mechanics and other material properties such as ligand chemistry and substrate degradability to regulate MSC differentiation has begun to be elucidated. Additionally, there are several changes in the presentation of these material properties as the dimensionality is altered from two- to three-dimensional substrates, which may fundamentally alter our understanding of substrate-induced mechanotransduction processes. In this review, an overview of recent findings that highlight the material properties that are important in guiding MSC fate decisions is presented, with a focus on underlining gaps in our existing knowledge and proposing potential directions for future research.

中文翻译：

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整合材料力学，配体化学，尺寸和降解的概念以控制间充质干细胞的分化。

在过去的十年中，底物力学在指导间充质干细胞（MSC）命运方面的作用一直是许多研究的重点。最近，已开始阐明底物力学与其他材料特性（例如配体化学和底物可降解性）之间复杂的相互作用，以调节MSC的分化。此外，随着材料尺寸从二维基材更改为三维基材，这些材料属性的表示方式也发生了一些变化，这可能会从根本上改变我们对基材诱导的机械转导过程的理解。在这篇评论中，概述了最近的发现，这些发现突出了对指导MSC命运决定至关重要的物质特性，