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Physiological Role of Two-Component Signal Transduction Systems in Food-Associated Lactic Acid Bacteria.
Advances in Applied Microbiology ( IF 5.515 ) Pub Date : 2017-01-18 , DOI: 10.1016/bs.aambs.2016.12.002
Vicente Monedero 1 , Ainhoa Revilla-Guarinos 2 , Manuel Zúñiga 1
Affiliation  

Two-component systems (TCSs) are widespread signal transduction pathways mainly found in bacteria where they play a major role in adaptation to changing environmental conditions. TCSs generally consist of sensor histidine kinases that autophosphorylate in response to a specific stimulus and subsequently transfer the phosphate group to their cognate response regulators thus modulating their activity, usually as transcriptional regulators. In this review we present the current knowledge on the physiological role of TCSs in species of the families Lactobacillaceae and Leuconostocaceae of the group of lactic acid bacteria (LAB). LAB are microorganisms of great relevance for health and food production as the group spans from starter organisms to pathogens. Whereas the role of TCSs in pathogenic LAB (most of them belonging to the family Streptococcaceae) has focused the attention, the roles of TCSs in commensal LAB, such as most species of Lactobacillaceae and Leuconostocaceae, have been somewhat neglected. However, evidence available indicates that TCSs are key players in the regulation of the physiology of these bacteria. The first studies in food-associated LAB showed the involvement of some TCSs in quorum sensing and production of bacteriocins, but subsequent studies have shown that TCSs participate in other physiological processes, such as stress response, regulation of nitrogen metabolism, regulation of malate metabolism, and resistance to antimicrobial peptides, among others.



中文翻译:

食品相关乳酸菌中两组分信号转导系统的生理作用。

两组分系统(TCS)是广泛存在的信号转导途径,主要存在于细菌中,它们在适应不断变化的环境条件中起着重要作用。TCS通常由传感器组氨酸激酶组成,它们会响应特定刺激而自磷酸化,随后转移磷酸基团与其关联的反应调节因子,因此通常作为转录调节因子来调节其活性。在这次审查中,我们提出上的的TCS在家庭种的生理作用目前的知识乳杆菌Leuconostocaceae组乳酸菌(LAB)的。乳酸菌是与健康和食品生产密切相关的微生物,因为该菌种从起始微生物到病原体。TCS在致病性LAB中的作用(其中大多数属于链球菌科)引起了人们的关注,而TCS在共生LAB中的作用,例如大多数乳酸杆菌科亮葡菌科,已经有所忽略。但是,现有证据表明,TCS是调节这些细菌生理的关键因素。与食物相关的LAB的第一项研究表明,某些TCS参与群体感应和细菌素生产,但随后的研究表明TCS参与其他生理过程,例如应激反应,氮代谢调节,苹果酸代谢调节,以及对抗菌肽的耐药性等。

更新日期:2017-01-18
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