The Hygiene Hypothesis has been recognized as an important cornerstone to explain the sudden increase in the prevalence of asthma and allergic diseases in modernized culture. The recent epidemic of allergic diseases is in contrast with the gradual implementation of Homo sapiens sapiens to the present-day forms of civilization. This civilization forms a gradual process with cumulative effects on the human immune system, which co-developed with parasitic and commensal Helminths. The clinical manifestation of this epidemic, however, became only visible in the second half of the twentieth century. In order to explain these clinical effects in terms of the underlying IgE-mediated reactions to innocuous environmental antigens, the low biodiversity of antigens in the domestic environment plays a pivotal role. The skewing of antigen exposure as a cumulative effect of reducing biodiversity in the immediate human environment as well as in changing food habits, provides a sufficient and parsimonious explanation for the rise in allergic diseases in a highly developed and helminth-free modernized culture. Socio-economic tendencies that incline towards a further reduction of environmental biodiversity may provide serious concern for future health. This article explains that the “Hygiene Hypothesis”, the “Old Friends Hypothesis”, and the “Skewed Antigen Exposure Hypothesis” are required to more fully explain the rise of allergy in modern societies.

中文翻译：

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环境抗原的倾斜暴露补充了解释过敏症增加的卫生假说

卫生假说已被公认为解释现代文化中哮喘和过敏性疾病患病率突然增加的重要基石。最近过敏性疾病的流行与智人逐渐应用于当今文明形式形成鲜明对比。这种文明形成了一个渐进的过程，对人类免疫系统产生累积影响，与寄生和共生蠕虫共同发展。然而，这种流行病的临床表现仅在 20 世纪下半叶才显现出来。为了从对无害环境抗原的潜在 IgE 介导反应来解释这些临床效应，家庭环境中抗原的低生物多样性起着关键作用。抗原暴露的倾斜作为减少人类直接环境中生物多样性以及改变饮食习惯的累积效应，为高度发达且无蠕虫的现代化文化中过敏性疾病的增加提供了充分而简洁的解释。趋向于进一步减少环境生物多样性的社会经济趋势可能会严重影响未来的健康。这篇文章解释了需要“卫生假说”、“老朋友假说”和“倾斜抗原暴露假说”来更全面地解释现代社会过敏症的兴起。为高度发达且无寄生虫的现代化文化中过敏性疾病的增加提供了充分而简洁的解释。趋向于进一步减少环境生物多样性的社会经济趋势可能会严重影响未来的健康。这篇文章解释了需要“卫生假说”、“老朋友假说”和“偏态抗原暴露假说”来更全面地解释现代社会过敏症的兴起。为高度发达且无寄生虫的现代化文化中过敏性疾病的增加提供了充分而简洁的解释。趋向于进一步减少环境生物多样性的社会经济趋势可能会严重影响未来的健康。这篇文章解释了需要“卫生假说”、“老朋友假说”和“倾斜抗原暴露假说”来更全面地解释现代社会过敏症的兴起。