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Is Triclosan a neurotoxic agent?
Journal of Toxicology and Environmental Health, Part B: Critical Reviews ( IF 7.2 ) Pub Date : 2017-03-25 , DOI: 10.1080/10937404.2017.1281181
Joanna A Ruszkiewicz 1 , Shaojun Li 2 , Maliya B Rodriguez 1 , Michael Aschner 1
Affiliation  

Triclosan (TCS) is an antibacterial agent that has been used in many products since 1960s. Given its broad usage as an antiseptic TCS is present ubiquitously in the environment. Trace levels of TCS continue to be detected in many organisms, and it has been shown to be particularly toxic to aquatic species. The mechanisms underlying TCS-mediated toxicity include hormone dyshomeostasis, induction of oxidative stress, apoptosis and inflammation. Although TCS has been considered to be non-toxic to mammals, the adverse effects of continuous, long-term and low concentration exposure remain unknown. Epidemiological studies revealed that levels of TCS in human tissues, urine, plasma and breast milk correlate with the usage of this antimicrobial. This led to concerns regarding TCS safety and potential toxicity in humans, with special emphasis on early development. The Food and Drug Administration (FDA) recently issued a directive banning the use of TCS in consumer soaps, justifying the move attributed to data gaps on its effectiveness and safety, indicating the need for more studies addressing this chemical-mediated effects on various tissues including the central nervous system (CNS). The aim of this review was to (1) summarize the current findings on the neurotoxic effects of TCS and given the paucity of data, to (2) broaden the discussion to other effects of TCS, which might plausibly be related to neuronal functions.

中文翻译:

三氯生是神经毒性剂吗?

自1960年代以来,三氯生(TCS)是一种抗菌剂,已在许多产品中使用。鉴于其广泛用作防腐剂TCS,它在环境中无处不在。在许多生物中仍继续检测到痕量的TCS,并且已证明对水生生物特别有毒。TCS介导的毒性的潜在机制包括激素动态平衡,氧化应激的诱导,细胞凋亡和炎症。尽管TCS被认为对哺乳动物无毒,但持续,长期和低浓度暴露的不利影响仍然未知。流行病学研究表明,人体组织,尿液,血浆和母乳中TCS的含量与该抗菌剂的使用有关。这引起了人们对TCS安全性和对人体潜在毒性的担忧,特别强调早期发展。美国食品药品监督管理局(FDA)最近发布了一项指令,禁止在消费类肥皂中使用TCS,从而证明此举是由于其有效性和安全性方面的数据空白所致,这表明需要进行更多的研究来解决这种化学介导的对各种组织的影响,包括中枢神经系统(CNS)。这篇综述的目的是(1)总结关于TCS的神经毒性作用的当前发现,并鉴于数据不足,(2)将讨论扩大到TCS的其他作用,这可能与神经元功能有关。表明需要进行更多研究来解决这种化学介导的对包括中枢神经系统(CNS)在内的各种组织的影响。这篇综述的目的是(1)总结关于TCS的神经毒性作用的当前发现,并鉴于数据不足,(2)将讨论扩大到TCS的其他作用,这可能与神经元功能有关。表明需要进行更多研究来解决这种化学介导的对包括中枢神经系统(CNS)在内的各种组织的影响。这篇综述的目的是(1)总结关于TCS的神经毒性作用的当前发现,并鉴于数据不足,(2)将讨论扩大到TCS的其他作用,这可能与神经元功能有关。
更新日期:2019-11-01
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