ABSTRACT

Studies using the sensitive periods framework typically examine the effects of early life exposures on later life health, due to the significant growth and development occurring during the first few years of life. The menopausal transition (i.e., perimenopause) is similarly characterized by rapid physiological change, yet rarely has been tested as a sensitive window in adulthood. Cohort mortality data drawn from three historic populations, Sweden (1751–1919), France (1816–1919), and England and Wales (1841–1919), were analyzed using time series methods to assess whether conditions at midlife significantly influenced or “programmed” later life longevity. Results indicated a significant inverse association between mortality at ages 45–49, the average age range in which perimenopause occurred, and life expectancy at age 60 among females in all three countries. Study findings suggest a degree of plasticity associated with women’s aging and, in particular, the age group correlated with perimenopause.

抽象的

由于在生命的最初几年中发生了显着的增长和发展，因此使用敏感期框架的研究通常会检查早期暴露对晚年健康的影响。绝经过渡期（即绝经期）的相似特征是生理快速变化，但很少被测试为成年期的敏感窗口。使用时间序列方法分析了来自三个历史人口的队列死亡率数据，其中三个历史人口是瑞典（1751-1919年），法国（1816-1919年）以及英格兰和威尔士（1841-1-19年），以评估中年情况是否受到显着影响或“已编程”以后的寿命长寿。结果表明，在45至49岁之间的死亡率（绝经发生的平均年龄范围）之间存在显着的负相关关系，这三个国家/地区的女性在60岁时的平均预期寿命。研究结果表明，可塑性与妇女的年龄有关，尤其是与围绝经期有关的年龄组。