Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.

中文翻译：

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通过Ugi反应合成氨促进的一锅四氮杂哌啶酮。

四唑Ugi变体中的氨与α-氨基酸甲基酯衍生的异氰化物一起在一个锅中以良好或高收率提供了四唑哌啶子酮。该反应的范围和局限性通过进行> 70个反应进行了研究。该支架可用于填充高通量筛选平台和基于结构的药物设计。