Objectives: Arsenic trioxide (As₂O₃) is a potent drug for acute promyelocytic leukaemia, but its clinical trials are allied with some serious adverse events mainly cardiac functional abnormalities. So the objective of our investigation is to identify the cardioprotective action of flaxseed oil (FSO), a natural compound against As₂O₃ induced cardiotoxicity.

Methods: Male wistar rats were treated with As₂O₃ (4 mg/kg) to induce cardiotoxicity. FSO (250 and 500 mg/kg) was given in combination with As₂O₃ for evaluating its cardioprotective efficacy.

Results: Treatment with As₂O₃ resulted in deposition of arsenic in heart tissue, increased cardiac marker enzymes release, lipid peroxidation (LPO), oxidative insults and pathological damages in the heart. Co-treatment with FSO (500 mg/kg) significantly reduced the arsenic accumulation, cardiac marker enzymes, LPO and cardiac structural alterations. FSO treatment significantly improved cardiac glutathione content, antioxidant enzymes and reduced the pathological damages in cardiac tissue. Gas chromatographic–mass spectrometry analysis revealed that the major fatty acid content in the FSO is alpha-linolenic acid, which has a strong milieu in cardiac health.

Conclusion: The results of the current investigation suggested that FSO is an effective agent in reducing arsenic-induced cardiac toxicity and can be used as an adjunct/dietary supplement for the cancer patients on As₂O₃ therapy.

目的：三氧化二砷（As ₂ O ₃）是一种有效的治疗急性早幼粒细胞白血病的药物，但其临床试验伴随着一些严重的不良事件，主要是心脏功能异常。因此，我们研究的目的是确定亚麻籽油（FSO）的心脏保护作用，亚麻籽油是对抗As ₂ O ₃诱导的心脏毒性的天然化合物。

方法：雄性Wistar大鼠用As ₂ O ₃（4 mg / kg）处理，诱发心脏毒性。将FSO（250和500 mg / kg）与As ₂ O ₃结合使用，以评估其心脏保护功效。

结果：用As ₂ O _3处理导致心脏组织中砷沉积，心脏标志物酶释放增加，脂质过氧化（LPO），氧化损伤和心脏病理损害。与FSO（500 mg / kg）共同治疗可显着减少砷积累，心脏标志物酶，LPO和心脏结构改变。FSO处理可显着改善心脏谷胱甘肽含量，抗氧化酶并减少心脏组织的病理损伤。气相色谱-质谱分析表明，FSO中的主要脂肪酸成分是α-亚麻酸，对心脏健康有很强的影响。

结论：目前的研究结果表明，FSO是降低砷引起的心脏毒性的有效药物，可作为癌症患者接受As ₂ O ₃疗法的辅助/饮食补充剂。