The aim is to determine whether serum drug concentrations obtained from the neonate's umbilical cord can be used as a prognostic factor for admission to the neonatology ward and the occurrence of withdrawal symptoms. A retrospective observational monocenter cohort study was carried out among pregnant women using psychotropic drugs and their baby. Binary logistic regression was used for the multivariate analysis. Of the 186 neonates included, 22.6% (n=42) were admitted to the neonatology ward, 6.5% (n=12) because of withdrawal. Among women with therapeutic concentrations of psychotropic medication, 22.0% (n=5) of the neonates had withdrawal symptoms. When comparing neonates with therapeutic versus undetectable drug concentrations, an odds ratio of 3.1 (95% confidence interval: 1.1-8.6) was found for admission to the neonatology ward and an odds ratio of 20.5 (95% confidence interval: 2.2-186.1) for the occurrence of withdrawal symptoms. Therapeutic concentrations of psychotropic drugs in neonates' umbilical cord blood correspond with higher odds for admission to the neonatology ward and the occurrence of withdrawal symptoms compared with neonates with undetectable drug concentrations. The measurement of drug concentrations in the neonate may contribute toward the general clinical assessment of the physician to predict the necessity of admission to the neonatology ward and the risk of withdrawal symptoms.

中文翻译：

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新生儿中精神药物的血清浓度是进入新生儿科病房和戒断症状的促进因素：PROOF-1。

目的是确定从新生儿脐带获得的血清药物浓度是否可用作进入新生儿科病房和出现戒断症状的预后因素。对使用精神药物的孕妇及其婴儿进行了回顾性单中心队列研究。二元逻辑回归用于多元分析。纳入的186例新生儿中，有22.6％（n = 42）入了新生儿科病房，有6.5％（n = 12）因退缩而入院。在使用精神药物治疗浓度的女性中，有22.0％（n = 5）的新生儿有戒断症状。当将新生儿与治疗药物浓度和无法检测的药物浓度进行比较时，优势比为3.1（95％置信区间：1.1-8。6）被发现要进入新生儿科病房，且出现戒断症状的比值比是20.5（95％置信区间：2.2-186.1）。与药物浓度无法检测的新生儿相比，新生儿脐带血中精神药物的治疗浓度与进入新生儿科病房的可能性更高，并且出现戒断症状的可能性更高。新生儿中药物浓度的测量可能有助于医师进行一般临床评估，以预测进入新生儿科病房的必要性和戒断症状的风险。与未检测到药物浓度的新生儿相比，脐带血入院新生儿科病房的几率更高，并且出现戒断症状的几率更高。新生儿中药物浓度的测量可能有助于医师进行一般临床评估，以预测进入新生儿科病房的必要性和戒断症状的风险。与未检测到药物浓度的新生儿相比，脐带血入院新生儿科病房的几率更高，并且出现戒断症状的几率更高。新生儿中药物浓度的测量可能有助于医师进行一般临床评估，以预测进入新生儿科病房的必要性和戒断症状的风险。