Acute extrapyramidal symptoms (EPS) occur frequently in schizophrenia, mostly caused by antidopaminergic substances. There have been no published reports on the impact of acute EPS on cerebral blood flow (CBF) or related measures. In the following study, we examined schizophrenic patients with and without EPS during a planning task and measurements of CBF velocity. Sixteen patients with chronic schizophrenia and 16 healthy participants performed a planning paradigm during bilateral functional transcranial Doppler sonography of the middle cerebral arteries. Patients with acute EPS showed blunted CBF velocity exclusively during difficult planning tasks, and correlation analyses confirmed that higher EPS scores were associated with reduced adaption of CBF velocity. EPS in schizophrenia are associated with a detrimental effect on CBF velocity. Hypothetically, compromised adaptation of cerebral hemodynamics during difficult, but not during easy planning tasks is one correlate of dysfunctional frontostriatal circuits in schizophrenic patients with EPS.

中文翻译：

---

精神分裂症的锥体外系症状：在计划任务期间大脑血流动力学减弱的证据。

精神分裂症中经常发生急性锥体外系症状（EPS），主要由抗多巴胺能物质引起。尚未有关于急性EPS对脑血流量（CBF）或相关措施的影响的公开报道。在以下研究中，我们在计划任务和CBF速度测量期间检查了患有和不患有EPS的精神分裂症患者。16位慢性精神分裂症患者和16位健康参与者在大脑中动脉的双侧功能性经颅多普勒超声检查期间执行了计划范式。急性EPS患者仅在困难的计划任务期间显示出CBF速度减弱，相关分析证实，较高的EPS得分与CBF速度适应性降低相关。精神分裂症中的EPS与CBF速度的有害影响有关。